A New Anthraquinone Isolated from Rumex Obtusifolius
نویسندگان
چکیده
In this research we studied Rumex obtusifolius (Polygonaceae) along with other plants used in traditional medicine in relation to the chemical reaction FBIT (Ferriprotoporphyrine Biocrystallization Inhibition Test) which may provide information on a possible action mechanism for presumed antimalarial plants. According to folk medicine Rumex obtusifolius has a pronounced detoxifying effect on the liver and is used against jaundice and fever. Following a chemical reaction-guided isolation on Rumex obtusifolius we obtained demethylmacrosporine I, an anthraquinone derivative. Its structural determination by one and two dimensional NMR and a proposition of structure-activity relationship are presented./En este trabajo estudiamos Rumex obtusifolius (Polygonaceae) junto a otras plantas usadas en la medicina tradicional respecto a la reacción química FBIT (Ensayo de Inhibición de la Biocristalización de la Ferriprotoporfirina), ensayo que puede proporcionar información de un posible mecanismo de acción de plantas presumidas antimalaricas. Según la medicina tradicional, Rumex obtusifolius posee un efecto desintoxicante del hígado y es usada contra la ictericia y la fiebre. Siguiendo una separación guiada por la reacción química en Rumex obtusifolius, obtuvimos la demethylmacrosporine I, un derivado antraquinonico. Su determinación estructural por RMN de una y dos dimensiones y una proposición de relación estructura actividad son presentadas.
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